Dr. Colin Seaton,Associate Professor
Information about Dr. Colin Seaton at the University of Bradford.
- School of Chemistry & Biosciences
(Faculty of Life Sciences) - Email:
- c.seaton@bradford.ac.uk
- Telephone:
- +44 1274 236155
Biography
Dr Colin Seaton received a first class BSc(Hons.) in Chemistry from the University of St. Andrews and a PhD in Chemistry froth University of Birmingham with a thesis entitled "Novel Methods of Crystal Structure Determination from Powder X-ray Diffraction Data".His Research lies in the field of crystal engineering with key interests in polymorphism, creation of multi-component crystals, crystal growth and habit modification. His work brings together both experimental and computational approaches to these problems with a interest in the application of biologically inspired computational methods such as evolutionary algorithms.
Teaching covers atomic and molecular structures, solid-state chemistry and computational chemistry.
Research
My research lies in the field of solid-state molecular chemistry, with the major focus on crystal engineering, the study of crystalline phases and controlling their formation. A key aim is the determination of the factors controlling the creation of crystal phases and using this understanding to design and create new materials. My work covers the development of both experimental (crystallisation processes, phase diagram construction, crystal structural determination by single crystal and powder diffraction methods) and computational methodologies (ab initio calculations, evolutionary algorithms) to gain the insight required.Current topics of interest include work on understanding influence of experimental conditions on polymorphism through molecular modelling of solvent/solute interactions and molecular conformation, the influence of chemical and crystallographic factors on proton transfer in crystal materials and the creation of multi-component crystals (salts and co-crystals). Development of new computational methodologies to model additive/crystal interactions, molecule/molecule interactions and location of low energy molecular conformations.
Research supervision
Dr. Colin Seaton is responsible for the supervision of 1 postgraduate researchers at the University of Bradford.
Research collaborators
| Name | Company | Country | Type | Role | Theme | Description |
|---|---|---|---|---|---|---|
| University of Lincoln | GB | EXTERNAL | Crystal Engineering | |||
| University of Lincoln | GB | EXTERNAL | Crystal Engineering |
Professional activities
Information about education, employment and areas of particular interest for Dr. Colin Seaton is as follows:
Employment
- University of Bradford - Lecturer in Chemistry in the year 2014 (specified as 01/02/2014)
- University of Limerick - Postdoctoral Research Fellow in the year 2011 (specified as 01/07/2011)
- University of Manchester - Part-Time Postdoctoral Research Associate in the year 2010 (specified as 01/09/2010)
- University of Bradford - Part-Time Teaching Associate in the year 2010 (specified as 01/09/2010)
- University of Manchester - Postdoctoral Research Associate in the year 2010 (specified as 01/06/2010)
- University of Bradford - Scientific Officer in the year 2009 (specified as 01/10/2009)
- University of Manchester - Postdoctoral Research Associate in the year 2008 (specified as 01/05/2008)
- University of Bradford - Postdoctoral Research Associate/Teaching Associate in the year 2003 (specified as 01/07/2003)
Education
- University of Birmingham - PhD
- University of St. Andrews - BSc (Hons)
Publications
There are 60 publications involving or that are attributed to Dr. Colin Seaton. They are listed as:
- other journal (1)
- peer reviewed journal (59)
Other Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Building Up Co-crystals: Structural Motif Consistencies Across Families of Co-crystals | 2021 | Proceedings | Proceedings | 78 | Colin C. Seaton | MDPI | https://doi.org/10.3390/IECP2020-08708 |
Peer Reviewed Journal
| Title | Year | Publication name | Journal | Volume | Pages | Authors | Editors | ISSN | Publisher | DOI | Location |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ordered Aggregation of Benzamide Crystals Induced using a "Motif Capper" Additive. | 2005 | Blagden, Nicholas; Song, M.; Davey, R.J.; Seton, L.; Seaton, Colin C. | |||||||||
| Tuning proton behavior in a ternary molecular complex. | 2010 | Thomas, L.H.; Blagden, Nicholas; Gutmann, M.J.; Kallay, A.A.; Parkin, A.; Seaton, Colin C.; Wilson, C.C. | |||||||||
| Formation of a hybrid coordination-molecular complex. | 2009 | Seaton, Colin C.; Scowen, Ian J.; Blagden, Nicholas | |||||||||
| Controlling the Formation of Benzoic Acid: Isonicotinamide Molecular Complexes. | 2009 | Seaton, Colin C.; Parkin, A.; Wilson, C.C.; Blagden, Nicholas | |||||||||
| Applying hot-stage microscopy to co-crystal screening: A study of nicotinamide with seven active pharmaceutical ingredients. | 2008 | Berry, David J.; Seaton, Colin C.; Clegg, W.; Harrington, R.W.; Coles, S.J.; Horton, P.N.; Hursthouse, M.B.; Storey, Richard; Jones, W.; Friščić, T.; Blagden, Nicholas | |||||||||
| Growth of an organic co-crystal upon a component subphase. | 2008 | Seaton, Colin C.; Parkin, A.; Wilson, C.C.; Blagden, Nicholas | |||||||||
| Creation of ternary multicomponent crystals by exploitation of charge-transfer interactions | 2013 | Seaton, Colin C.; Blagden, Nicholas; Munshi, Tasnim; Scowen, Ian J. | |||||||||
| Multi-component crystals of 4-phenylpyridine: challenging the boundaries between co-crystal and organic salt formation with insight into solid-state proton transfer | 2013 | Seaton, Colin C.; Munshi, Tasnim; Williams, Sara E.; Scowen, Ian J. | |||||||||
| Stabilisation of metastable polymorphs: the case of paracetamol form III | 2016 | Telford, Richard; Seaton, Colin C.; Clout, A.; Buanz, A.B.M.; Gaisford, S.; Williams, G.R.; Prior, T.J.; Okoye, C.H.; Munshi, Tasnim; Scowen, Ian J. | |||||||||
| Thermal Behavior of Benzoic Acid/Isonicotinamide Binary Cocrystals | 2015 | Buanz, A.B.M.; Prior, T.J.; Burley, J.C.; Raimi-Abraham, B.T.; Telford, Richard; Hart, M.; Seaton, Colin C.; Davies, P.J.; Scowen, Ian J.; Gaisford, S.; Williams, G.R. | |||||||||
| Proton location in acid⋯pyridine hydrogen bonds of multi-component crystals | 2014 | Seaton, Colin C. | |||||||||
| Proton transfer and hydrogen bonding in the organic solid state: a combined XRD/XPS/ssNMR study of 17 organic acid–base complexes | 2014 | Stevens, J.S.; Byard, S.J.; Seaton, Colin C.; Sadiq, G.; Davey, R.J.; Schroeder, S.L.M. | |||||||||
| Investigating the dissolution of the metastable triclinic polymorph of carbamazepine using in situ microscopy | 2014 | O'Mahony, M.; Seaton, Colin C.; Croker, D.M.; Veesler, S.; Rasmuson, A.K.; Hodnett, B.K. | |||||||||
| Racemic compound versus conglomerate: concerning the crystal chemistry of the triazoylketone, 1-(4-chlorophenyl)-4,4- dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-one | 2014 | Davey, R.J.; Sadiq, G.; Seaton, Colin C.; Pritchard, R.G.; Coquerel, G.; Rougeot, C. | |||||||||
| Creation of a ternary complex between a crown ether, 4-aminobenzoic acid and 3,5-dinitrobenzoic acid | 2014 | Boardman, N.D.; Munshi, Tasnim; Scowen, Ian J.; Seaton, Colin C. | |||||||||
| Complete Colloidal Synthesis of Cu2SnSe3 Nanocrystals with Crystal Phase and Shape Control | 2014 | Wang, J.; Liu, P.; Seaton, Colin C.; Ryan, K.M. | |||||||||
| Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents | 2014 | Maher, A.; Croker, D.M.; Seaton, Colin C.; Rasmuson, Å.C.; Hodnett, B.K. | |||||||||
| Investigation into solid and solution properties of quinizarin | 2015 | Cheuk, D.; Svärd, M.; Seaton, Colin C.; McArdle, P.; Rasmuson, Å.C. | |||||||||
| Are the Crystal Structures of Enantiopure and Racemic Mandelic Acids Determined by Kinetics or Thermodynamics? | 2015 | Hylton, R.K.; Tizzard, G.J.; Threlfall, T.L.; Ellis, A.L.; Coles, S.J.; Seaton, Colin C.; Schulze, E.; Lorenz, H.; Seidel-Morgenstern, A.; Stein, M.; Price, S.L. | |||||||||
| Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology | 2018 | Korde, Sachin A.; Pagire, Sudhir K.; Pan, H.; Seaton, Colin C.; Kelly, Adrian L.; Chen, Y.; Wang, Q.; Coates, Philip D.; Paradkar, Anant R. | |||||||||
| Poly(acrylic acid) interpolymer complexes | 2017 | RSC Soft Matter | 13 | Swift, Thomas; Seaton, Colin C.; Rimmer, Stephen | |||||||
| Structural Motifs in Salts of Sulfathiazole: Implications for Design of Salt Forms in Pharmaceuticals APIs | 2018 | Seaton, Colin C.; Rayan, R.T.; Essifaow, E.A.A.; Nauha, E.; Munshi, Tasnim; Scowen, Ian J. | |||||||||
| Molecular versus crystal symmetry in tri-substituted triazine, benzene and isocyanurate derivatives | 2006 | Acta Crystallographica Section B: Structural Science | 62 | 864 - 874 | Chong S.;Seaton C.;Kariuki B.;Tremayne M. | 0108-7681 | 10.1107/S0108768106020921 | ||||
| An unusual Cu(II) complex of a Schiff-base ligand of 3-aminoquinoline with a hydronated pyridine unit: Synthesis, characterizations, and computational studies | 2016 | Polyhedron | 107 | 172 - 175 | Nayak S.;Pevec A.;Seaton C.;Gamez P.;Reedijk J. | 0277-5387 | 10.1016/j.poly.2016.01.009 | ||||
| Designing hydrogen bonds with temperature-dependent proton disorder: The effect of crystal environment | 2007 | Crystal Growth and Design | 7 | 531 - 534 | Parkin A.;Seaton C.;Blagden N.;Wilson C. | 1528-7483 | 10.1021/cg060777p | ||||
| Building Multi-Component Crystals From Cations and Co-crystals: The Use of Chaperones | 2013 | CrystEngComm | 15 | 2241 - 2250 | Bukenya S.;Munshi T.;Scowen I.;Skyner R.;Whitaker D.;Seaton C. | 1466-8033 | 10.1039/c2ce26498f | ||||
| Current directions in co-crystal growth | 2008 | New Journal of Chemistry | 32 | 1659 - 1672 | Blagden N.;Berry D.;Parkin A.;Javed H.;Ibrahim A.;Gavan P.;De Matos L.;Seaton C. | 1144-0546 | 10.1039/b803866j | ||||
| A combination of X-ray Single-crystal diffraction and Monte Carlo Structure Solution from X-ray Powder Diffraction Data in a structural investigation of 5-bromonicotinic acid and solvates thereof | 2001 | Crystal Growth and Design | 1 | Aakeroy CB; Beatty, AM; Tremayne, M; Rowe, DM; Seaton CC | |||||||
| Differential evolution: Crystal structure determination of a triclinic polymorph of adipamide from powder diffraction data | 2002 | Chemical Communications | 2 | 880 - 881 | Seaton C.;Tremayne M. | 1359-7345 | 10.1039/b200436d | ||||
| Structures of three substituted arenesulfonamides from X-ray powder diffraction data using the differential evolution technique | 2002 | Acta Crystallographica Section B: Structural Science | 58 | 823 - 834 | Tremayne M.;Seaton C.;Glidewell C. | 0108-7681 | 10.1107/S0108768102011928 | ||||
| Characterization of complicated new polymorphs of chlorothalonil by X-ray diffraction and computer crystal structure prediction | 2004 | Journal of the American Chemical Society | 126 | 7071 - 7081 | Tremayne M.;Grice L.;Pyatt J.;Seaton C.;Kariuki B.;Tsui H.;Price S.;Cherryman J. | 0002-7863 | 10.1021/ja0498235 | ||||
| Co-crystallization in the caffeine/maleic acid system: Lessons from phase equilibria | 2010 | Crystal Growth and Design | 10 | 268 - 273 | Guo K.;Sadiq G.;Seaton C.;Davey R.;Yin Q. | 1528-7483 | 10.1021/cg900885n | ||||
| Designing acid/acid co-crystals through the application of hammett substituent constants | 2010 | Crystal Growth and Design | 10 | 726 - 733 | Seaton C.;Chadwick K.;Sadiq G.;Guo K.;Davey R. | 1528-7483 | 10.1021/cg9011235 | ||||
| Solubility, metastable zone width measurement and crystal growth of the 1:1 benzoic acid/isonicotinamide cocrystal in solutions of variable stoichiometry | 2010 | Journal of Pharmaceutical Sciences | 99 | 3779 - 3786 | Boyd S.;Back K.;Chadwick K.;Davey R.;Seaton C. | 0022-3549 | 10.1002/jps.22184 | ||||
| The phase behavior and crystallization of 2-chloromandelic acid: The crystal structure of the pure enantiomer and the behavior of its metastable conglomerate | 2011 | Crystal Growth and Design | 11 | 1549 - 1556 | Lorenz H.;Von Langermann J.;Sadiq G.;Seaon C.;Davey R.;Seidel-Morgenstern A. | 1528-7483 | 10.1021/cg1015077 | ||||
| Making benzamide cocrystals with benzoic acids: The influence of chemical structure | 2011 | Crystal Growth and Design | 11 | 1502 - 1511 | Seaton C.;Parkin A. | 1528-7483 | 10.1021/cg101403j | ||||
| Epitaxial growth of polymorphic systems: The case of sulfathiazole | 2011 | CrystEngComm | 13 | 5903 - 5907 | Munroe A.;Croker D.;Hodnett B.;Seaton C. | 1466-8033 | 10.1039/c1ce05585b | ||||
| Creating carboxylic acid co-crystals: The application of Hammett substitution constants | 2011 | CrystEngComm | 13 | 6583 - 6592 | Seaton C. | 1466-8033 | 10.1039/c1ce05645j | ||||
| Crystallography aided by atomic core-level binding energies: Proton transfer versus hydrogen bonding in organic crystal structures | 2011 | Angewandte Chemie - International Edition | 50 | 9916 - 9918 | Stevens J.;Byard S.;Seaton C.;Sadiq G.;Davey R.;Schroeder S. | 1433-7851 | 10.1002/anie.201103981 | ||||
| The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach | 2012 | Chemical Communications | 48 | 1976 - 1978 | Davey R.;Sadiq G.;Back K.;Wilkinson L.;Seaton C. | 1359-7345 | 10.1039/c1cc16173c | ||||
| Investigation of the solid-state polymorphic transformations of piracetam | 2012 | Crystal Growth and Design | 12 | 6223 - 6233 | Maher A.;Seaton C.;Hudson S.;Croker D.;Rasmuson A.;Hodnett B. | 1528-7483 | 10.1021/cg301418c | ||||
| Solution mediated phase transformations between co-crystals | 2013 | CrystEngComm | 15 | 2044 - 2047 | Croker D.;Davey R.;Rasmuson A.;Seaton C. | 1466-8033 | 10.1039/c2ce26801a | ||||
| Tuning proton disorder in 3,5-dinitrobenzoic acid dimers: The effect of local environment | 2013 | Crystal Growth and Design | 13 | 497 - 509 | Jones A.;Blagden N.;McIntyre G.;Parkin A.;Seaton C.;Thomas L.;Wilson C. | 1528-7483 | 10.1021/cg300906j | ||||
| Investigation into the mechanism of solution-mediated transformation from FI to FIII carbamazepine: The role of dissolution and the interaction between polymorph surfaces | 2013 | Crystal Growth and Design | 13 | 1861 - 1871 | O'Mahony M.;Seaton C.;Croker D.;Veesler S.;Rasmuson A.;Hodnett B. | 1528-7483 | 10.1021/cg301456m | ||||
| Nucleation in the p-toluenesulfonamide/triphenylphosphine oxide co-crystal system | 2013 | Crystal Growth and Design | 13 | 3754 - 3762 | Croker D.;Davey R.;Rasmuson A.;Seaton C. | 1528-7483 | 10.1021/cg400780e | ||||
| Insight into the Mechanism of Formation of Channel Hydrates via Templating | 2014 | Stokes, S.P.; Seaton, Colin C.; Eccles, K.S.; Maguire, A.R.; Lawrence, S.E. | |||||||||
| Improving Stability of Effervescent Products by Co-Crystal Formation: A Novel Application of Crystal Engineered Citric Acid | 2020 | Crystal Growth and Design | 20 | 4839 - 4844 | Pagire, SK; Seaton, CC; Paradkar, A | ACS | https://doi.org/10.1021/acs.cgd.0c00616 | ||||
| Ortho -Substituent effect on the crystal packing and solid state speciation of aromatic C -nitroso compounds | 2020 | CrystEngComm | 22 | 5040 - 5048 | Pike S.J.;Heliot A.;Seaton C.C. | 1466-8033 | 10.1039/d0ce00728e | ||||
| Intriguing High Z″ Cocrystals of Emtricitabine | 2020 | Crystal Growth and Design | 20 | 4886 - 4891 | Palanisamy V.;Sanphui P.;Bolla G.;Narayan A.;Seaton C.C.;Vangala V.R. | 1528-7483 | 10.1021/acs.cgd.0c00744 | ||||
| Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology | 2018 | Crystal Growth and Design | 18 | 2297 - 2304 | Korde, S.; Pagire, S.; Pan, H.; Seaton, C.; Kelly, A.; Chen, Y.; Wang, Q.; Coates, P.; Paradkar, A. | https://doi.org/10.1021/acs.cgd.7b01733 | |||||
| Isostructurality of quinoxaline crystal phases: The interplay of weak hydrogen bonds and halogen bonding | 2021 | CrystEngComm | 23 | 7108 - 7117 | Saidykhan A.;Fenwick N.W.;Bowen R.D.;Telford R.;Seaton C.C. | 1466-8033 | 10.1039/d1ce00878a | ||||
| Influence of Terminal Functionality on the Crystal Packing Behaviour and Cytotoxicity of Aromatic Oligoamides. | 2021 | FRONTIERS IN CHEMISTRY | 9 | Delfosse P;Seaton CC;Male L;Lord RM;Pike SJ; | 2296-2646 | 10.3389/fchem.2021.709161 | |||||
| Structural similarity in chiral-achiral multi-component crystals | 2020 | CrystEngComm | 22 | 7334 - 7340 | Scowen I.J.;Alomar T.S.;Munshi T.;Seaton C.C. | 1466-8033 | 10.1039/d0ce00301h | ||||
| Anticancer water-soluble organoruthenium complexes: synthesis and preclinical evaluation. | 2022 | ChemBioChem | e202200259 | Pitto-Barry A;Azmanova M;Rafols L;Cooper PA;Seaton CC;Shnyder SD; | 1439-7633 | 10.1002/cbic.202200259 | |||||
| Artemisinin-acetylenedicarboxylic acid cocrystal: Screening, structure determination, and physicochemical property characterisation | 2022 | CrystEngComm | 24 | 1056 - 1067 | Makadia J.;Madu S.J.;Arroo R.;Seaton C.C.;Li M. | 1466-8033 | 10.1039/d1ce01400e | ||||
| Construction of Ternary Phase Diagrams: Application of Quantitative NMR | 2022 | Crystal Growth and Design | 22 | 1724 - 1730 | Telford R.;Obule W.;Seaton C.C. | 1528-7483 | 10.1021/acs.cgd.1c01311 | ||||
| Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria. | 2022 | Current Research In Microbial Sciences | 3 | Nolan VC;Rafols L;Harrison J;Soldevila-Barreda JJ;Crosatti M;Garton NJ;Wegrzyn M;Timms DL;Seaton CC;Sendron H;Azmanova M;Barry NPE;Pitto-Barry A;Cox JAG; | 2666-5174 | 10.1016/j.crmicr.2021.100099 | |||||
| Interfacial Cocrystallization Using Oily Phase via Liquid−Liquid Phase Separation | 2022 | CRYSTAL GROWTH & DESIGN (ONLINE) | 22 | M. Asim Sajid Al-Hanafi, Mhd Bashir Alsirawan, Colin C. Seaton, Thomas Swift, Sudhir Pagire, Venu R. Vangala, Adrian L. Kelly, and Anant Paradkar | https://doi.org/10.1021/acs.cgd.2c00263 | ||||||
| Investigation into the development of novel lanthanide-based luminescent colorants for application to textiles and paper materials | 2023 | Coloration Technology | D M Lewis, P J Broadbent, M L A Rigout, C M Carr*, C C Seaton, and T Swift | https://doi.org/10.1111/cote.12675 |